2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040134
    Mal-amido-PEG4-NHS ester 756525-99-2 99.18%
    Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG4-NHS ester
  • HY-129622A
    NH2-PEG5-C6-Cl hydrochloride 2241669-16-7 ≥98.0%
    NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG5-C6-Cl hydrochloride
  • HY-124480
    Tetrazine-Ph-acid 1380500-92-4 98.67%
    Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-acid
  • HY-140417
    t-Boc-Aminooxy-PEG4-NHS ester 2401831-99-8 99.90%
    t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG4-NHS ester
  • HY-126959
    Biotin-PEG4-acid 721431-18-1
    Biotin-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG4-acid
  • HY-140830
    m-PEG12-azide 2170098-29-8 98.6%
    m-PEG12-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG12-azide
  • HY-113931
    Aminooxy-PEG2-azide 1043426-13-6
    Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG2-azide
  • HY-130211
    Azido-PEG5-alcohol 86770-68-5
    Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-alcohol
  • HY-W018365
    Tetraethylene glycol monomethyl ether 23783-42-8 99.35%
    Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethylene glycol monomethyl ether
  • HY-140888
    Biotin-PEG2-NHS ester 596820-83-6
    Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-NHS ester
  • HY-75005
    1-Boc-4-carboxymethyl piperazine 156478-71-6
    1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 (HY-168586)).
    1-Boc-4-carboxymethyl piperazine
  • HY-141177
    TCO-PEG2-amine 2141981-87-3
    TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG2-amine
  • HY-141364
    Bromo-PEG1-C2-Boc 1393330-36-3 98.58%
    Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-C2-Boc
  • HY-130893
    Biotin-EDA 111790-37-5
    Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-EDA
  • HY-W017970
    Boc-C2-NH2 15231-41-1 99.63%
    Boc-C2-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C2-NH2
  • HY-30756
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate 236406-55-6 99.89%
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332).
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate
  • HY-133399
    Alkyne-PEG4-maleimide 1609651-90-2 ≥98.0%
    Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-PEG4-maleimide
  • HY-W040236
    m-PEG8-Amine 869718-81-0 ≥98.0%
    m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG8-Amine
  • HY-118764
    Propargyl-PEG2-acid 1859379-85-3 ≥98.0%
    Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-acid
  • HY-42151
    Mal-amido-PEG2-C2-acid 756525-98-1 99.58%
    Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-acid
PROTAC Linkers Isoform Comparison

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